Publications of Biocentre

Publications of the staff members of HAN BioCentre.

Publications B.C. Lokman Ph.D

  • Chapter 12: Heterologous Expression of Peroxidases, de Weert S, Lokman BC: Biocatalysis Based on Heme Peroxidases, (Peroxidases as Potential Industrial Biocatalysts), E. Torres and M. Ayala (Eds.), Springer, ISBN 978-3-642-12627-7
  • Joosten V, Roelofs MS, van den Dries N, Goosen T, Verrips CT, van den Hondel CA, Lokman BC. Production of bifunctional proteins by Aspergillus awamori: llama variable heavy chain antibody fragment (V(HH)) R9 coupled to Arthromyces ramosus peroxidase (ARP). J Biotechnol. 2005 Dec 6;120(4):347-59. Epub 2005 Sep 16
  • Joosten V, Gouka RJ, van den Hondel CA, Verrips CT, Lokman BC. Expression and production of llama variable heavy-chain antibody fragments (VHH)s) by Aspergillus awamori. Appl Microbiol Biotechnol. 2005 Jan;66(4):384-92. Epub 2004 Sep 17. Erratum in: Appl Microbiol Biotechnol. 2005 Mar;66(6):737
  • Punt PJ, Drint-Kuijvenhoven A, Lokman BC, Spencer JA, Jeenes D, Archer DA, van den Hondel CA. The role of the Aspergillus niger furin-type protease gene in processing of fungal proproteins and fusion proteins. Evidence for alternative processing of recombinant (fusion-) proteins. J Biotechnol. 2003 Dec 5;106(1):23-32
  • Lokman BC, Joosten V, Hovenkamp J, Gouka RJ, Verrips CT, van den Hondel CA. Efficient production of Arthromyces ramosus peroxidase by Aspergillus awamori. J Biotechnol. 2003 Jun 26;103(2):183-90
  • Joosten V, Lokman BC, Van Den Hondel CA, Punt PJ. The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. Microb Cell Fact. 2003 Jan 30;2(1):1.
  • Chaillou S, Lokman BC, Leer RJ, Posthuma C, Postma PW, Pouwels PH. Cloning, sequence analysis, and characterization of the genes involved in isoprimeverose metabolism in Lactobacillus pentosus. J Bacteriol. 1998 May;180(9):2312-20
  • Lokman BC, Heerikhuisen M, Leer RJ, van den Broek A, Borsboom Y, Chaillou S, Postma PW, Pouwels PH. Regulation of expression of the Lactobacillus pentosus xylAB operon. J Bacteriol. 1997 Sep;179(17):5391-7
  • Lokman BC. Regulations of the genes involved in D-xylose catabolism of Lactobacillus pentosus. PhD thesis. 1996
  • Lokman BC, Leer RJ, van Sorge R, Pouwels PH. Promoter analysis and transcriptional regulation of Lactobacillus pentosus genes involved in xylose catabolism. Mol Gen Genet. 1994 Oct 17;245(1):117-25.
  • Lokman BC, van Santen P, Verdoes JC, Kruse J, Leer RJ, Posno M, Pouwels PH. Organization and characterization of three genes involved in D-xylose catabolism in Lactobacillus pentosus. Mol Gen Genet. 1991 Nov;230(1-2):161-9.
  • Posno M, Heuvelmans PT, van Giezen MJ, Lokman BC, Leer RJ, Pouwels PH. Complementation of the inability of Lactobacillus strains to utilize D-xylose with D-xylose catabolism-encoding genes of Lactobacillus pentosus. Appl Environ Microbiol. 1991 Sep;57(9):2764-6
  • Posno M, Leer RJ, van Luijk N, van Giezen MJ, Heuvelmans PT, Lokman BC, Pouwels PH. Incompatibility of Lactobacillus Vectors with Replicons Derived from Small Cryptic Lactobacillus Plasmids and Segregational Instability of the Introduced Vectors.Appl Environ Microbiol. 1991 Jun;57(6):1822-1828

Publications N. van Biezen B.Sc

  • te Biesebeke R, van Biezen N, Boussier A, Braaksma M, van den Hondel CAMJJ, de Vos WM, Punt PJ. Oveproduction of Aspergillus hemoglobin domains in Aspergillus oryzae grown on solid substrates improves growth rate and enzyme production. Biotechnology Journal 2006. (Submitted)
  • te Biesebeke R, Record E, van Biezen N, Heerikhuisen M, Franken A, Punt PJ, van den Hondel CA. Branching mutants of Aspergillus oryzae with improved amylase and protease production on solid substrates. Appl Microbiol Biotechnol. 2005 Nov;69(1):44-50
  • te Biesebeke R, van Biezen N, de Vos WM, van den Hondel CA, Punt PJ. Different control mechanisms regulate glucoamylase and protease gene transcription in Aspergillus oryzae in solid-state and submerged fermentation. Appl Microbiol Biotechnol. 2005 Apr;67(1):75-82
  • te Biesebeke R, Boussier A, van Biezen N, van den Hondel CAMJJ, Punt PJ. Identification of secreted proteins of Aspergillus oryzae associated with growth on solid cereal substrates. Journal of Biotechnol 121 (2006) 482-485
  • Punt P.J., van Biezen N., Conesa A., Albers A., Magnus J. and van den Hondel C. (2002). Filamentous fungi as cell factories for heterologous protein production. Trends in Biotechnology 10:1-7
  • van Biezen N.A., Lekanne Deprez R.H., Thijs A., Heutink P., Oostra B.A., Geurts van Kessel A.H.M. and Zwarthoff E.C. (1992). Isolation and characterization of 25 unique DNA markers for human chromosome 22. Genomics 15:206-208
  • Lekanne Deprez R.H., van Biezen N.A., Breedveld G.J., Boejharat K.R.G.S., de Klein A., Geurts van Kessel A.H.M. and Zwarthoff E.C. (1991). A new polymorphic probe on chromosome 22: NB5 (D22S201). Nucleic Acids Res. 19:1963
  • Lekanne Deprez R.H., van Biezen N.A., Heutink P., Boejharat K.R.G.S., de Klein A., Geurts van Kessel A.H.M. and Zwarthoff E.C. (1991). A new polymorphic probe on chromosome 22: NB17 (D22S181), NB35 (D22S182), NB84 (D22S183), NB129 (D22S184). Nucleic Acids Res. 19:686-687.
  • Lekanne Deprez R.H., Groen N.A., van Biezen N.A., Hagemeijer A., van Drunen E., Koper J.W., Avezaat C.J.J., Bootsma D. and Zwarthoff E.C. (1991). A t(4;22) in a meningioma points to the localization of a putative tumor-suppressor gene. Am. J. Hum. Genet. 48:783-790
  • Lekanne Deprez R.H., Groen N.A., van Biezen N.A., Hagemeijer A., van Drunen E., Koper J.W., Avezaat C.J.J., Bootsma D. and Zwarthoff E.C. (1991). A t(4;22) in a meningioma points to the localization of a putative tumor-suppressor gene. Am. J. Hum. Genet. 48:783-790

Publications A. Thiele Ph.D

  • Thiele, A., Nagamine, Y., Hauschildt, S., Clevers, H. (2006) Regulation of b-catenin mRNA stability by alternative splicing and AU-rich elements in the b-catenin 3´UTR. Experimental Cell Research, 312(12):2367-2378
  • van Es, J.H., Jay, P., Gegorieff, A., van Gijn, M., Jonkheer, S., Hatzis, P., Thiele, A., van den Born, M., Begthel, H., Brabletz, T., Taketo, M.M., Clevers, H. (2005) Wnt signaling induces maturation of Paneth cells in intestinal crypts. Nature Cell Biology 7(4), 381-386
  • Thiele, A., Kronstein, R., Wetzel, A., Nieber, K., Hauschildt, S. (2004) Involvement of adenosine receptor subtypes in preventing LPS-induced respiratory burst during cultivating of human monocytes. Infection an Immunity 72(3), 1349-1357
  • Thiele, A., Bang, R., Gütschow, M., Rossol, M., Loos, S., Eger, K., Tiegs, G., Hauschildt, S. (2002) Cytokine modulation ans suppression of liver injury by a novel analogue of thalidomide. European Journal of Pharmacology, 452, 325-334
  • Thiele, A., Pfister, M., Erbes, M., Cross, M., Hänsch, M., Hauschildt, S. (2002) Novobiocin is a novel inducer of CD38 on cells of the myelomonocytic lineage. Biochimica et Biophysica Acta, 1542, 32-40
  • Thiele, A., Wasner, M., Müller, C., Engeland, K., Hauschildt, S. (2001) Regulation and possible function of b-catenin in humon monocytes. Journal of Immunology, 167(12), 6786-6793
  • Gütschow, M., Hecker, T., Thiele, A., Hauschildt, S., Eger, K. (2001) Aza analogues of thalidomide: synthesis and evaluation as inhibitors of tumor necrosis factor-a production in vitro. Bioorganic & Medicinal Chemistry 9, 1059-1065
  • Thiele, A., Thormann, M., Hofmann, H.-J., Naumann, W. W., Eger, K., Hauschildt, S. (2000) A Possible role of N-cadherin in thalidomide teratogenicity. Life Sciences 67, 457-461

Publications D. Lamers B.Sc

  • van de Graaf SF, Hoenderop JG, Gkika D, Lamers D, Prenen J, Rescher U, Gerke V, Staub O, Nilius B, Bindels RJ. Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J. 2003 Apr 1;22(7):1478-87. PMID: 12660155 [PubMed - indexed for MEDLINE]